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Part career sweeping memoir, part inspirational playbook, Big Bets offers a master class in decision-making, leadership, and changing the world one bet at a time. These are big-bet decisions with a broad impact and significant value at stake for organizations. They’re also risky and often involve a high degree of uncertainty. If you wait for certainty, the chance to make a bold move – say, about strategic direction, M&A and resource allocation – usually has vanished.

Rajiv J. Shah is no stranger to pulling off the impossible, from helping vaccinate 900 million children at the Bill & Melinda Gates Foundation to a high-pressure race against the clock to stop the spread of Ebola. His secret?
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Here is a just a selection of the big bets the Foundation has made over 112 years — and is making today. Eradicating a disease making life worse across the American South. An estimated 40% of the region’s people, especially the most vulnerable, suffered from hookworm disease which made people prone to other illnesses and extreme fatigue.

A disease that causes a deadly hemorrhagic fever could spread around the world. The president and his team made a big bet—they would deploy U.S. troops and first responders into West Africa to beat back the pandemic there, to . A disease that causes a deadly hemorrhagic fever could spread around the world. The president and his team made a big bet—they would deploy U.S. troops and first responders into West Africa to beat back the pandemic there, to .big bets Big Bets A disease that causes a deadly hemorrhagic fever could spread around the world. The president and his team made a big bet—they would deploy U.S. troops and first responders into West Africa to beat back the pandemic there, to .Big Bets Big bets are pivotal decisions leaders make when the stakes are high decisions that forge a successful path or retrieve a lost cause at a critical crossroads. Big bets can determine a company's destiny or reshape its future.We identified the Big Bet problems, goals, strategies, and desired impacts to contribute to an outcome over a specific period of time. We considered a series of guiding questions as we were Thinking About a Big Bet.
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